Lung cancer accounted for 28% of all cancer related deaths in hong kong and has been the leading cause of cancer death worldwide. Peptidecoated liposomal fasudil enhances site specific. Determine the response rate in patients with small cell lung cancer treated with sn38 liposome that is dosed according to a ugt1a1 specific genotype. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. Full text hl95012 lung specific drug delivery systems for tuberculosis treatment nih guide, volume 24, number 1, january, 1995 rfa.
Pdf lung cancer is fatal and spreading rapidly worldwide. This study establishes that carconjugated inhalable liposomal fasudil offers favorable pharmacokinetics and produces pulmonary vasculature specific dilatation. A liposome is a spherical vesicle having at least one lipid bilayer. Apr 20, 2017 antibodydecorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to the lung by targeting a recognition factor present on the surface of lung tumor cells. Antibody targeting of doxorubicinloaded liposomes suppresses. The aim is to use ha liposomes to develop an inhalatory treatment for these diseases. Disadvantages of liposomes in drug delivery despite all the wonderful advantages, liposomes do have some disadvantages when compared with other methods of drug delivery. Site specific drug delivery 441 liposome targeting 441 ligandbearing liposomes 444 glycolipid and glycoprotein ligandbearing liposomes 445. Today, they are a very useful reproduction, reagent, and tool in various. Efficient biodistribution and gene silencing in the lung. These liposomes are conventional liposomes cl or long circulating liposomes lcl with antibody or other recognition sequences attached to the surface. If you continue browsing the site, you agree to the use of cookies on this website. Ge11modified liposomes for nonsmall cell lung cancer.
Expression of the cystic fibrosis transmembrane conductance regulator cftr gene. Liposomes can be made to just interact with specific organisms. Lung cancer, hyaluronic acid ha, haasesensitive dualtargeting irinotecan liposomes, antitumor efficiency, intracellular delivery. Paclitaxel targeting to lungs by way of liposomes prepared by. The purpose of this study was to develop novel pirfenidone pfdloaded liposomes for targeting to the lung. The role of tumor and drug specific parameters in local delivery to tumors hendriks et al 2 results computational model we constructed a computational model of the kinetic steps in the transport of doxorubicin into tumor cells to quantify the role of liposome and tumor specific parameters on liposomal drug delivery figure 1. Lung cancer is the leading cause of cancerrelated death in worldwide.
Liposomes a novel drug delivery system slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. These carriers can entrap a wide range of therapeutic molecules for delivery in large volumes to the peripheral airways using medical nebulizers. Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email pdf copies to you promptly. Mice were injected with a single iv administration of a,d dirstained liposomes, b liposomes containing af750 tagged sirna, or c unstained liposomes. Haasesensitive dualtargeting irinotecan liposomes enhance. Therapeutic liposomal dry powder inhalation aerosols for.
Repeat administration of dnaliposomes to the nasal. Liposomes coated with isolated macrophage membrane can target. Confocal microscopy of b1 integrinpositive lung tumor cells incubated with fluorescently labeled antib1 fab immunoliposomes revealed a tumorspecific binding and efficient internalization of the liposomes into the tumor cells. Structural biochemistryliposomes wikibooks, open books for. This study demonstrated that syndecan1 liposomes were able to release cargo into igf1r expressing tumor cells. Tissue distribution of these liposomes showed more accumulation in lungs than in reticuloendothelial systems res of normal and tuberculous mice. Antilungcancer activity and liposomebased delivery systems. Conventional antituberculous medications frequently have serious side effects. One recent promising development in the modification of drug formulations to improve chemotherapy is the use of a liposomemediated drug delivery system. Liposomes for drug delivery to the lung 434 liposome pharmacokinetics in the lung 435 lung targeting 438 18.
The specific targeting of liposomes towards the alveolar macrophages can be achieved by coating the liposomes with alveolar macrophage specific ligands such as ostearyl amylopectin osap. Antibody targeting of doxorubicinloaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice1 masahiko sugano,2 nejat k. Lung cancertargeting peptides with multisubtype indication. Based on the low polydispersion index, the liposomes are uniform in size fig. In attempts to increase the specificity of interaction between liposomes and tumor cells, recent efforts in the liposome field have focused on the development of active tumortargeted liposomes, which were modified with specific ligands such as tf, folic acid, peptides 69 or antibodies 1012, and could selectively recognize and bind.
Lung specific stealth liposomes as antitubercular drug carriers in guinea pigs. Surface functionalization and targeting strategies of. Since this mechanism is specific to igf1rpositive cells, chemotherapeutic agents may be loaded into sdc1 liposomes and delivered only to tumor cells. Yokota, fangan chen,3 jennifer harding, shi kun huang, and richard b. Liposomes encapsulated drugs require a high production cost. A gamma scintigraphy study to investigate lung deposition. In order to develop a novel lung targeting drug delivery system ltdds with largesized liposomes containing paclitaxel ptx, the liposomes composed of ptx, phosopholipon 90h and tween80 were prepared by the effervescent dispersion technique with optimal formulation composition. Antilungcancer activity and liposomebased delivery. Liposomes can aide with active targeting as it has flexibility in coupling with site specific ligands. It increases the affinity of liposomes to specific cells. Lung cancer is globally the leading cause of all cancer deaths among both men and women.
The liposomes were intravenously injected in tuberculous and normal mice and animals were sacrificed at different time intervals. The paclitaxel liposomes produced a drug concentration in the lung that was markedly higher than that in other organs or tissues and was about 15. What are liposomes liposomes are concentric bilayered vesicles in which an aqueous core is entirely enclosed by a membranous lipid bilayer mainly composed of natural or synthetic phospholipids. Efficacy of dualfunctional liposomes containing paclitaxel. Liposomes, sphereshaped vesicles consisting of one or more phospholipid bilayers, were first described in the mid60s. In several cases, organ specific depletion can be obtained by choosing the right administration route for the clodronate liposomes. In a previous study, lungspecific localization of liposomes was observed after endotracheal administration of the liposomes. In this paper, we summarize the advanced progress being made in antilung cancer activity and the new liposomes delivery systems of. Effective targeting of solid tumors in patients with. Determine the toxicity of this drug in these patients. Liposomes can be prepared by disrupting biological membranes such as by sonication liposomes are most often composed of phospholipids, especially phosphatidylcholine, but may also include other lipids, such as egg.
Subjects and protocol this was a singleperiod gamma scintigraphy study, designed to determine the lung deposition and clearance of. The authors suggested that the liposomal formulation helps in the persistence of rifampicin in the lung tissue. Liposomes coated with isolated macrophage membrane can. In this paper, we summarize the advanced progress being made in anti lung cancer activity and the new liposomes delivery systems of. As these therapies approach clinical realization, it is becoming increasingly clear that the ability to efficiently deliver gene transfer agents gtas to target cell populations within the lung may prove just as critical as the gene therapy formulation itself in terms of generating. Antigen specific suppression of inflammatory arthritis using liposomes. Enhanced localization of liposomes with prolonged blood circulation time in infected lung tissue irma a. The delivery of triptolide to nonsmall cell lung cancer. Drug showed decreases bacteria count in lung, increased bioavailability and decreased lung injury caused by bacteria. Pdf therapeutic efficacies of isoniazid and rifampin. Ge11modified liposomes for nonsmall cell lung cancer targeting. The size of liposomes observed by tem is smaller than dls 129 nm, fig. The liposome can be used as a vehicle for administration of nutrients and pharmaceutical drugs.
Liposome encapsulation was done in various ways for the delivery of different drugs such as metaproterenol into liposomes caused. Liposomes for drug delivery durgavati yadav 1, kumar sandeep 2. Multiscale kinetic modeling of liposomal doxorubicin. Enhanced localization of liposomes with prolonged blood. Liposomal sn38 in treating patients with small cell lung. The mechanism of surfactant lipid recycling, which is an important physiological process in surfactant treatment, was studied in type ii cells isolated from injured lungs. In more recent investigations, pyrazinamide and rifabutincontaining liposomes were also produced. Lung cancer is the most commonly diagnosed cancer and is the leading cause of cancer deaths among males and females worldwide. Liposomes for specific depletion of macrophages from. Using a nanocarrier of this sort can reduce the incidence and intensity of side effects, which results in improved patient compliance and prognosis. Hyaluronic aciddecorated liposomes as innovative targeted.
Vaccines pulmonary surfactant biomimetic nanoparticles. Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and biology. Pulmonary delivery of transferrin receptors targeting. Tumor specific liposomes improve detection of pancreatic. Interstitial lung disease spain pdf ppt case reports. In order to lower toxicity, liposomes are made to avoid certain areas, also known as. Liposomes with ha of two molecular weights were prepared and characterized. Impaired recycling of surfactantlike liposomes in type ii. Interstitial lung disease of unknown cause is predominated by idiopathic pulmonary fibrosis, a specific and progressive fibrotic lung disease, followed by the idiopathic interstitial pneumonias, such as nonspecific interstitial pneumonia nsip, and sarcoidosis. Determine, preliminarily, overall and progressionfree. Pulmonary delivery of triptolideloaded liposomes decorated. The liposomes also have a slight positive charge of 0. The uptake of radiolabeled liposomes in tumor and in specific organs liver, spleen, kidney, and lung was estimated by measuring the total number of counts in identical roi on the geometric mean images anterior and posterior derived from the emission scans and correcting for attenuation of the body using the transmission images. Lung specific stealth liposomes as antitubercular drug.
Lung gene therapy is being evaluated for a range of acute and chronic diseases, including cystic fibrosis cf. Therefore, ongoing research aims at enhancing the tumor site specific action of the liposomes by attaching ligands to surface molecules of tumor cells and tumor vasculature, a process called active or ligandmediated targeting liposomes 5, 6, 75. The survival rate of this cancer is much less than the other prevalent cancers. At 48 hours after injection, lung tissue was harvested, sectioned, and stained for cd146, cd326, and dapi nuclear stain and analyzed via.
Reports of inh and rifampin encapsulated in lung specific stealth liposomes against mtb infection revealed that liposomeencapsulated drugs at and below therapeutic concentrations were more effective than free drugs against tb pandey et al. It was observed that aerosols of interleukin 2 liposomes were biologically stable and retained in the lung after nebulization 15. Cancer metastasis leads to high mortality of breast cancer and is difficult to treat because of the poor delivery efficiency of drugs. Ex vivo analysis showed that nontargeted liposomes accumulated in the liver, suggesting that specificity of the liposomes for pancreatic adenocarcinoma was due to the presence of the syndecan1 ligand. Aerosol delivery of dnaliposomes to the lung for cystic. Nonsmall cell lung cancer nsclc is the most common lung cancer 85% and has been linked to poor prognosis with 5year survival rates of only 15%. Functionalization of liposomes with a suitable ligand, i. Key words liposomes macrophages clodronate depletion of macrophages kupffer cells spleen liver lung lymph nodes. In vivo, the macrophage membrane enabled the liposome to target metastatic cells and produced a notable inhibitory effect on lung metastasis of breast cancer. Hyaluronic acid ha plays a key role in fibrosis with its specific receptor, cd44, overexpressed by ctdild and bos cells. The efficacies of isoniazid and rifampin encapsulated in lung specific stealth liposomes were evaluated by injecting liposomal drugs and free drugs into tuberculous mice twice a week for 6 weeks. Surfactant synthesis and secretion has been shown to be impaired in type ii cells from diseased lungs. Conclusions to sum up, these results demonstrated that the paclitaxel liposomes are an effective lung targeted carrier in the treatment of lung cancer.
The lungspecific stealth liposomes were prepared by incorporating 0. Liposomes also showed a continuous release of the drug over 5 days, suggesting a prolonged lung specific delivery of the drug. Liposomes a novel drug delivery system from miss snehal k. Research article vaccines pulmonary surfactantbiomimetic nanoparticles potentiate heterosubtypic influenza immunity ji wang1,2, peiyu li1,3,yang yu1,yuhong fu3, hongye jiang 1, min lu, zhiping sun 3, shibo jiang, lu lu3, mei x.
The discovery of new drug molecules remains timeconsuming, expensive, and prone to failure in safetyefficacy studies. Pulmonary diseases 0740022 microbiology national heart, lung, and blood institute letter of intent receipt date. Overall, the physicochemical properties of the liposomes demonstrated the feasibility for inhalational formulation of an antipah drug. Medical nanoparticles for next generation drug delivery to the lungs sabine h. Peptidemediated liposomal drug delivery system targeting. Different stages of lung injury were induced by exposing rats to 10 ppm nitrogen dioxide. Aug 23, 2018 the treatment of cancer is a great challenge to medical professionals as the search for a medical treatment that can distinguish between healthy rapidly dividing cells and abnormal cancerous cells. In summary, ge11modified liposomes may be a promising platform for targeted delivery of chemotherapeutic drugs in nsclc.
Effective targeting of solid tumors in patients with locally. The major cause of mortality in patients with cystic fibrosis cf is lung disease. Determine, preliminarily, overall and progressionfree survival of patients treated with this drug. April 7, 1995 purpose the national heart, lung, and blood institute nhlbi. Liposomes are established drug carriers for inhalation owing to their safety and ability to provide controlled drug release in the lung. Lung cancertargeting peptides with multisubtype indication for combinational drug delivery and molecular imaging yihsuan chi1, 2, jongkai hsiao3, minghuang lin4, chen chang4, chunhsin lan1 and hanchung wu1, 2 1.
Mar 04, 2005 determine the response rate in patients with small cell lung cancer treated with sn38 liposome that is dosed according to a ugt1a1 specific genotype. Institute of cellular and organismic biology, academia sinica, taipei, taiwan. Liposome as a drug delivery system shows great advantages over traditional formulations for. Using a nanocarrier of this sort can reduce the incidence and intensity of side effects, which results in improved patient compliance and prognosis 6 8, 10. Herein, we report the wrapping of a drugcarrying liposome with an isolated macrophage membrane to improve delivery to metastatic sites. Expression of the cystic fibrosis transmembrane conductance regulator cftr gene product in the airways is a. Wu1 current influenza vaccines only confer protection against homologous viruses. Medical nanoparticles for next generation drug delivery to. Therapeutic efficacies of isoniazid and rifampin encapsulated.
Liposomes for specific depletion of macrophages from organs. Systematic development and optimization of inhalable. Peptidelinked liposomal fasudil, as opposed to plain liposomes, reduced the mean pulmonary arterial pressure by 3540%, without influencing the mean systemic arterial pressure. In 2018, there were 200,000 newly diagnosed cases of lung cancer, with an estimated 142,000 deaths 1. Our results provide a biomimetic strategy via the biological properties of macrophages to enhance the medical performance of a nanoparticle in vivo for treating cancer metastasis. Pharmaceutics free fulltext systematic development and. Nonsmall cell lung cancer nsclc is a global disorder, treatment options for which remain limited with resistance development by cancer cells and offtarget events being major roadblocks for current therapies.
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